Kia ora,
Welcome to PADLOC!
The Prokaryotic Antiviral Defence LOCator
PADLOC-DB v2.0.0 includes many new candidate systems, including several Hma–Embedded Candidate (HEC) systems, and hundreds of additional Phage Defence Candidate (PDC) systems. These systems were identified through a 'guilt-by-embedding' approach, where defence function was inferred for proteins encoded between the genes of known systems (Payne et al., unpublished).
Developed by: The Jackson Lab, University of Otago, Aotearoa New Zealand.
Please cite:
The PADLOC web server and precomputed RefSeq data:
Payne L.J., Meaden S., Mestre M.R., Palmer C., Toro N., Fineran P.C. and Jackson S.A.* (2022)
PADLOC: a web server for the identification of antiviral defence systems in microbial genomes.
Nucleic Acids Research 50, W541-W550. doi:
10.1093/nar/gkac400
The PADLOC command line tool:
Payne L.J., Todeschini T.C., Wu, Y., Perry B.J., Ronson C.W., Fineran P.C., Nobrega F.L. and Jackson S.A.* (2021)
Identification and classification of antiviral defence systems in bacteria and archaea with PADLOC reveals new system types.
Nucleic Acids Research 49, 10868-10878. doi:
10.1093/nar/gkab883